----------------------Benzodiazepine
Dose----------Comparative Time to peak plasma level------------------------Half
Life Alprazolam----------------.5------------------------------------------------1
- 2-----------------------------------------------9 - 20 Clonazepam--------------.25-----------------------------------------------1
- 4----------------------------------------------19 - 60
This chart (from the above link) looks for the
equivalent dose of a given benzo to equal 5 mg of diazepam (valium).
So, you need .5mg of alprazolam (xanax) to equal 5
mg of valium, but you only need .25 mg of clonazepam (klonopin) to equal 5 mg
of valium.
The klonopin is, as you said, slower in action. it
takes up to 4 hours to reach full effect where the xanax will be in full effect
by 2 hours at the latest.
However, klonopin has amuchlonger
half life than xanax, so it will stay in your system longer. The long half life
of klonopin is why doctors like it. You are less likely to become addicted to
it as you do not need to continually take more klonopin throughout the day to
keep anxiety at bay, so you don't get into the habit of "popping
pills" and you don't experience break-through anxiety.
As for getting the same feel from klonopin as you
get from xanax... there is another reason doctors prefer klonopin and that is
that xanax has a mild euphoric effect that klonopin and other benzos do not
have. That mild euphoria increases the chance that patients will become
habituated to and possibly misuse their medication. So, basically, klonopin is
actually stronger than xanax in terms of efficacy, but if what you are looking
for is that mild euphoria, (which isn't what benzos are for) you can't replicate
that.
Depression strikes millions each year, often with debilitating consequences. This psychological
disorder is so common that it is sometimes referred to as the "common cold" of mental health, with nearly 10%
of the population suffering from a depressive disorder at any given time.
Depression also has a high cure rate. Effective treatments exist to help bring people's lives back under
control. Yet tragically many people suffering from this illness go without
diagnosis and treatment. This depression test is a tool that may help you recognize the symptoms of
depression and decide to get help. Please note that only a licensed professional can diagnose depression.
Xanax (alprazolam) belongs to a group of drugs
called benzodiazepines. It works by slowing down the movement of chemicals in
the brain that may become unbalanced. This results in a reduction in nervous
tension (anxiety).
Xanax is used to treat anxiety disorders, panic
disorders, and anxiety caused by depression.
Xanax may also be used for purposes not listed in
this medication guide.
Important information about Xanax
Do not use Xanax if you are pregnant. It could harm
the unborn baby. Do not use Xanax if you are allergic to alprazolam or to other
benzodiazepines, such as chlordiazepoxide (Librium), clorazepate (Tranxene),
diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax).
Before you take Xanax, tell your doctor if you have
asthma or other breathing problems, glaucoma, kidney or liver disease, a
history of alcoholism, or a history of depression, suicidal thoughts, or
addiction to drugs or alcohol.
Do not drink alcohol while taking Xanax. This
medication can increase the effects of alcohol. Xanax may be habit-forming and
should be used only by the person for whom it was prescribed. Keep the
medication in a secure place where others cannot get to it.
Before taking Xanax
It is dangerous to try and purchase Xanax on the
Internet or from vendors outside of the United States. Medications distributed
from Internet sales may contain dangerous ingredients, or may not be
distributed by a licensed pharmacy. Samples of Xanax purchased on the Internet
have been found to contain haloperidol (Haldol), a potent antipsychotic drug
with dangerous side effects. For more information, contact the U.S. Food and
Drug Administration (FDA) or visit www.fda.gov/buyonlineguide.
You should not take Xanax if you have:
·narrow-angle
glaucoma;
·if you
are also taking itraconazole (Sporanox) or ketoconazole (Nizoral); or
·if you
are allergic to alprazolam or to other benzodiazepines, such as
chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium),
lorazepam (Ativan), or oxazepam (Serax).
To make sure you can safely take Xanax, tell your
doctor if you have any of these other conditions:
·asthma,
emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other
breathing problems;
·glaucoma;
·kidney or
liver disease (especially alcoholic liver disease);
·a history
of depression or suicidal thoughts or behavior; or
·a history
of drug or alcohol addiction.
Xanax may be habit forming and should be used only
by the person for whom it was prescribed. Never share Xanax with another
person, especially someone with a history of drug abuse or addiction. Keep the
medication in a place where others cannot get to it.
FDA pregnancy category D. Do not use Xanax if you
are pregnant. It could harm the unborn baby. Xanax may also cause addiction or
withdrawal symptoms in a newborn if the mother takes the medication during
pregnancy. Use effective birth control, and tell your doctor if you become
pregnant during treatment. Alprazolam can pass into breast milk and may harm a
nursing baby. You should not breast-feed while you are using this medicine. The
sedative effects of Xanax may last longer in older adults. Accidental falls are
common in elderly patients who take benzodiazepines. Use caution to avoid
falling or accidental injury while you are taking Xanax. Do not give this
medication to anyone under 18 years old
What happens if I overdose?
Seek emergency medical attention or call the Poison
Help line at 1-800-222-1222. An overdose of Xanax can be fatal. Overdose
symptoms may include extreme drowsiness, confusion, muscle weakness, loss of
balance or coordination, feeling light-headed, and fainting.
What should I avoid while taking Xanax?
Do not drink alcohol while taking Xanax. This
medication can increase the effects of alcohol. Xanax may impair your thinking
or reactions. Be careful if you drive or do anything that requires you to be
alert.
Grapefruit and grapefruit juice may interact with
Xanax and lead to unwanted side effects. Discuss the use of grapefruit products
with your doctor
Xanax side effects
Get emergency medical help if you have any of these
signs of an allergic reaction to Xanax: hives; difficult breathing; swelling of
your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side
effect such as:
·depressed mood, thoughts of suicide or hurting
yourself, unusual risk-taking behavior, decreased inhibitions, no fear of danger;
Using
Xanax, especially for a prolonged period, can have numerousdrug abuse effectson your body. The medication is a
central nervous system depressant, so most of the effects have to do with how
your mind functions. The most commoneffects of
Xanax useinclude lack
of coordination, slurred speech, confusion and disorientation.
Some
people develop memory impairment, which typically only affects the short-term
memory, and doctors primarily see mild cases of impairment. Sedation is also a
concern for Xanax users. People who take the mediation in large doses might
experience severe sedation that can last for three to four days.
Xanax
Abuse Treatment
People
suffering from Xanax addictions have the option to use inpatient or outpatient
treatment programs. It is important that you review what every program has to
offer. Then, choose the program that has the best chance of helping you
succeed.
Inpatient
treatment programs give you a stable and temptation-free environment for your
recovery. Centers have around-the-clock care. The medical staff will help you
cope with your withdrawal symptoms and may administer medication to make the
symptoms subside. A typical day in an inpatient facility could include group
therapy sessions, individual therapy sessions and educational lectures.
Outpatient
treatment programs give you more freedom, and there are two different options.
The daily check-in program requires you to check in with a drug abuse counselorevery day,
while the day treatment program requires you to be at the center for eight
hours each day. Meanwhile, you will be attending therapy sessions and possibly
educational lectures about addiction and recovery.
Nitrazepam
(Nite-raz-ep-am) is a medicine which is used in sleeping problems.
The
information in this Medicine Guide for nitrazepam varies according to the
condition being treated and the particular preparation used.
Your medicine
Nitrazepam
should only be used at the lowest possible dose and for a maximum of up to four
weeks. This will reduce the chance of tolerance, dependence and withdrawal
symptoms.
Some
people, in the course of taking Nitrazepam for a sleeping problem, may find
that an undiagnosed psychiatric condition, such as depression, becomes
apparent. People who have a psychiatric condition and who are taking Nitrazepam
may experience some changes in behaviour.
It is
essential to get at least seven or eight hours continuous and uninterrupted
sleep after taking Nitrazepam. If you are woken before this time has passed,
Nitrazepam may cause you to have some memory problems. You may have no memory
of what happened from the time you were woken until the time when the effects of
this medicine have worn off.
Do not
share your medicine with other people. It may not be suitable for them and may
harm them.
The
pharmacy label on your medicine tells you how much medicine you should take. It
also tells you how often you should take your medicine. This is the dose that
you and your prescriber have agreed you should take. You should not change the
dose of your medicine unless you are told to do so by your prescriber.
If you
feel that the medicine is making you unwell or you do not think it is working,
then talk to your prescriber.
Whether this medicine is suitable for you
Nitrazepam
is not suitable for everyone and some people should never use it. Other people
should only use it with special care. It is important that the person
prescribing this medicine knows your full medical history.
Your
prescriber may only prescribe this medicine with special care or may not
prescribe it at all if you:
·are allergic or sensitive to or have had a bad reaction to
benzodiazepines in the past
·are allergic or sensitive to or have had a reaction to any of
the ingredients in the medicine
·are debilitated
·are elderly
·have a personality disorder
·have a phobic or obsessional disorder
·have abused alcohol in the past
·have anxiety with depression
·have been treated with Nitrazepam over a long period of time
·have breathing problems
·have depression
·have had a recent loss or bereavement
·have kidney problems
·have liver problems
·have lung problems
·have misused drugs in the past
·have myasthenia gravis
·have organic brain syndrome
·have psychosis
·have sleep apnoea syndrome
Nitrazepam is not used
in children.
Over time it is possible that Nitrazepam can become unsuitable
for some people, or they may become unsuitable for it. If at any time it
appears that Nitrazepam has become unsuitable, it is important that the
prescriber is contacted immediately.
Alcohol
Alcohol can interact with certain medicines.
In the case of Nitrazepam:
·alcohol may increase the sedative effects of Nitrazepam
You must not drink any alcohol if you are taking this medicine.
Diet
Medicines can interact with certain foods. In some cases, this
may be harmful and your prescriber may advise you to avoid certain foods.
In the case of Nitrazepam:
·there are no specific foods that you must exclude from your diet
when taking Nitrazepam
Driving and operating
machinery
When taking any medicine you should be aware that it might
interfere with your ability to drive or operate machinery safely.
In the case of Nitrazepam:
·this medicine could affect your ability to drive or operate
machinery
You should see how this medicine affects you before you judge
whether you are safe to drive or operate machinery. If you are in any doubt
about whether you should drive or operate machinery, talk to your prescriber.
Family planning and
pregnancy
Most medicines, in some way, can affect the development of a
baby in the womb. The effect on the baby differs between medicines and also
depends on the stage of pregnancy that you have reached when you take the
medicine.
In the case of Nitrazepam:
·you should only take this medicine during pregnancy if your
doctor thinks that you need it
·if you become pregnant, or think you have become pregnant while
taking Nitrazepam, you must contact your prescriber
·if you take this medicine during your pregnancy, your baby may
have some problems after birth. Also, if you repeatedly take this medicine
during the late stages of pregnancy, your baby may come to be physically
dependent on Nitrazepam. This may lead to your baby having withdrawal symptoms
from Nitrazepam after birth
You need to discuss your specific circumstances with your doctor
to weigh up the overall risks and benefits of taking this medicine. You and
your doctor can make a decision about whether you are going to take this
medicine during pregnancy.
If the decision is that you should not have Nitrazepam, then you
should discuss whether there is an alternative medicine that you could take
during pregnancy.
Breast-feeding
Certain medicines can pass into breast milk and may reach your
baby through breast-feeding.
In the case of Nitrazepam:
·women who are breast-feeding must not take this medicine
Before you have your baby you should discuss breast-feeding with
your doctor or midwife. They will help you decide what is best for you and your
baby based on the benefits and risks associated with this medicine. If you wish
to breast-feed you should discuss with your prescriber whether there are any
other medicines you could take which would also allow you to breast-feed. You
should not stop this medicine without taking advice from your doctor.
Taking other medicines
If you are taking more than one medicine they may interact with
each other. At times your prescriber may decide to use medicines that interact,
in other cases this may not be appropriate.
The decision to use medicines that interact depends on your
specific circumstances. Your prescriber may decide to use medicines that
interact, if it is believed that the benefits of taking the medicines together
outweigh the risks. In such cases, it may be necessary to alter your dose or
monitor you more closely.
Tell your prescriber the names of all the medicines that you are
taking so that they can consider all possible interactions. This includes all
the medicines which have been prescribed by your GP, hospital doctor, dentist,
nurse, health visitor, midwife or pharmacist. You must also tell your
prescriber about medicines which you have bought over the counter without
prescriptions.
The following medicines may interact with Nitrazepam:
·rifampicin
The following types of medicine may interact with Nitrazepam:
·anaesthetics
·analgesics
·antidepressants
·antiepileptics
·antipsychotics
·barbiturates
·hydantoins
·hypnotics
·liver enzyme inducers
·liver enzyme inhibitors
·medicines that act on the central nervous system
·sedative antihistamines
·tranquillisers
Nitrazepam is not used
in children.
Over time it is possible that Nitrazepam can become unsuitable
for some people, or they may become unsuitable for it. If at any time it
appears that Nitrazepam has become unsuitable, it is important that the
prescriber is contacted immediately.
Alcohol
Alcohol can interact with certain medicines.
In the case of Nitrazepam:
·alcohol may increase the sedative effects of Nitrazepam
You must not drink any alcohol if you are taking this medicine.
Diet
Medicines can interact with certain foods. In some cases, this
may be harmful and your prescriber may advise you to avoid certain foods.
In the case of Nitrazepam:
·there are no specific foods that you must exclude from your diet
when taking Nitrazepam
Driving and operating
machinery
When taking any medicine you should be aware that it might
interfere with your ability to drive or operate machinery safely.
In the case of Nitrazepam:
·this medicine could affect your ability to drive or operate
machinery
You should see how this medicine affects you before you judge
whether you are safe to drive or operate machinery. If you are in any doubt
about whether you should drive or operate machinery, talk to your prescriber.
Family planning and
pregnancy
Most medicines, in some way, can affect the development of a
baby in the womb. The effect on the baby differs between medicines and also
depends on the stage of pregnancy that you have reached when you take the
medicine.
In the case of Nitrazepam:
·you should only take this medicine during pregnancy if your
doctor thinks that you need it
·if you become pregnant, or think you have become pregnant while
taking Nitrazepam, you must contact your prescriber
·if you take this medicine during your pregnancy, your baby may
have some problems after birth. Also, if you repeatedly take this medicine
during the late stages of pregnancy, your baby may come to be physically
dependent on Nitrazepam. This may lead to your baby having withdrawal symptoms
from Nitrazepam after birth
You need to discuss your specific circumstances with your doctor
to weigh up the overall risks and benefits of taking this medicine. You and
your doctor can make a decision about whether you are going to take this
medicine during pregnancy.
If the decision is that you should not have Nitrazepam, then you
should discuss whether there is an alternative medicine that you could take
during pregnancy.
Breast-feeding
Certain medicines can pass into breast milk and may reach your
baby through breast-feeding.
In the case of Nitrazepam:
·women who are breast-feeding must not take this medicine
Before you have your baby you should discuss breast-feeding with
your doctor or midwife. They will help you decide what is best for you and your
baby based on the benefits and risks associated with this medicine. If you wish
to breast-feed you should discuss with your prescriber whether there are any
other medicines you could take which would also allow you to breast-feed. You
should not stop this medicine without taking advice from your doctor.
Taking other medicines
If you are taking more than one medicine they may interact with
each other. At times your prescriber may decide to use medicines that interact,
in other cases this may not be appropriate.
The decision to use medicines that interact depends on your
specific circumstances. Your prescriber may decide to use medicines that
interact, if it is believed that the benefits of taking the medicines together
outweigh the risks. In such cases, it may be necessary to alter your dose or
monitor you more closely.
Tell your prescriber the names of all the medicines that you are
taking so that they can consider all possible interactions. This includes all
the medicines which have been prescribed by your GP, hospital doctor, dentist,
nurse, health visitor, midwife or pharmacist. You must also tell your
prescriber about medicines which you have bought over the counter without
prescriptions.
The following medicines may interact with Nitrazepam:
·rifampicin
The following types of medicine may interact with Nitrazepam:
·anaesthetics
·analgesics
·antidepressants
·antiepileptics
·antipsychotics
·barbiturates
·hydantoins
·hypnotics
·liver enzyme inducers
·liver enzyme inhibitors
·medicines that act on the central nervous system
·sedative antihistamines
·tranquillisers
If you are taking Nitrazepam and one of the above medicines or
types of medicines, make sure your prescriber knows about it.
Complementary preparations
and vitamins
Medicines can interact with complementary preparations and
vitamins. In general, there is not much information available about
interactions between medicines and complementary preparations or vitamins.
If you are planning to take or are already taking any complementary
preparations and vitamins you should ask your prescriber whether there are any
known interactions with Nitrazepam.
Your prescriber can advise whether it is appropriate for you to
take combinations that are known to interact. They can also discuss with you
the possible effect that the complementary preparations and vitamins may have
on your condition.
If you experience any unusual effects while taking this medicine
in combination with complementary preparations and vitamins, you should tell you’re
prescriber.
Side-effects
A medicine is only made available to the public if the clinical trials have shown that the benefits of taking the medicine outweigh the risks.
Once a medicine has been licensed, information on the medicine's effects, both intended and unintended, is continuously recorded and updated.
Some side-effects may be serious while others may only be a mild inconvenience.
Everyone's reaction to a medicine is different. It is difficult to predict which side-effects you will have from taking a particular medicine, or whether you will have any side-effects at all. The important thing is to tell your prescriber or pharmacist if you are having problems with your medicine.
The frequency of these side-effects is unknown
balance or coordination problems
behavioural problems seek medical advice if you develop symptoms of depression including suicidal tendencies, paradoxical aggressive outbursts, rages, inappropriate behaviour, excitement, confusion, restlessness, agitation, irritability, delusions, nightmares, hallucinations, psychoses or other behavioural problems
blood and bone marrow problems
changes in libido
confusion
daytime sedation
dose tolerance
double vision
eye or eyesight problems
failure of Nitrazepam to achieve the intended medical effect - if Nitrazepam is repeatedly used for a few weeks
feeling dizzy
feeling emotionally numb
gastrointestinal problems
headaches
hypersensitivity reactions including rash, angioedema and high blood pressure
jaundice
lowered blood pressure
memory problems - these may lead to behavioural changes
muscle weakness
precipitation of suicide in people with depression
psychological problems
reduced alertness
relaxed muscles - this may lead to an increased risk of falling or hip fractures. You should be careful when moving around after you have taken Nitrazepam
side effects that may occur if Nitrazepam is taken at a high dose for long period of time. These may include physical and physiological dependence which may lead to drug abuse
skin rash or rashes
tiredness
uncovering depression
urinary retention
vertigo
withdrawal symptoms or rebound phenomena can occur when this medicine is stopped. These include depression, headaches, muscle weakness, nervousness, anxiety, tension, restlessness, confusion, convulsion, mood changes, rebound insomnia, psychotic-like behaviour, irritability, sweating and diarrhoea. If withdrawal is severe the following may occur: derealisation, depersonalisation, numbness, over-sensitive hearing and tingling of the extremities, hypersensitivity to light, noise and physical contact, hallucinations or seizures